Clinical Research Directory

INCLUSION CRITERIA: CSCR Cases: 1. Adults (\> 18 years old) 2. Active fovea-involving CSCR 3. Both of the following major diagnostic criteria\*: 1. Presence of SRF within the central 1mm subfield (circular zone of 1mm diameter centred on the foveal umbo) on OCT scan 2. At least 1 area of RPE alteration on fundus autofluorescence, OCT or infrared imaging 4. Any one of the following minor diagnostic criteria\*: 1. Sub-foveal choroidal thickness ≥ 400 µm on OCT 2. ≥ 1 focal leak on FFA 3. Mid-phase hyperfluorescent placoid areas on ICGA 5. First episode or a distinct recurrent episode 6. Duration of current episode \< 180 days 7. No other cause for the above findings (e.g. diabetic retinopathy, exudative age-related macular degeneration, or polypoidal choroidal vasculopathy) * Inclusion criteria based on the Central Serous Chorioretinopathy International Group diagnostic criteria for idiopathic CSCR.13 According to these criteria, an FFA and ICG are not required for diagnosis if choroidal thickness on OCT is ≥ 400 µm. Therefore, review OCT before performing FFA and/or ICGA. Non-CSCR Cases: 1. Adults (\> 18 years old) 2. Approximately age- and sex-matched to CSCR cases 3. No CSCR 4. No other BCVA-affecting ocular disease or condition EXCLUSION CRITERIA: Study eye: 1. Any treatment for current or previous CSCR with PDT or laser 2. Use of any topical medication for CSCR currently, or in the last 90 days 3. Use of topical steroids or carbonic anhydrase inhibitors currently, or in the last 90 days 4. Intraocular anti-VEGF therapy in the last 180 days 5. Intraocular steroids in the last 180 days or intraocular steroid implant in the last 3 years 6. Treatment with retinal or macular laser at any point (except peripheral laser retinopexy at least 90 days prior) 7. Cryotherapy within 90 days 8. Previous cyclodiode therapy at any point 9. Laser refractive surgery within 90 days 10. Intraocular surgery within 90 days 11. Presence of any other disease that could cause retinal or SRF (e.g. diabetic retinopathy, exudative age-related macular degeneration, or polypoidal choroidal vasculopathy) 12. Current or prior retinal or choroidal neovascularisation of any cause 13. Diabetic retinopathy 14. Presence of any other disease which is thought to be currently affecting BCVA, or likely to do so during study participation 15. Media opacity precluding fundus examination and/or imaging (e.g. dense cataract) General: 16. Current, recent (within 90 days) or anticipated (during study participation) treatment with systemic anti-VEGF therapy, oral/intravenous/intramuscular steroids, systemic carbonic anhydrase inhibitors or systemic hormone therapy (except hormonal contraception) 17. Current or recent (within 90 days) practice of regular (more than twice per week) meditation or mindfulness 18. Unable, unwilling or unlikely to undertake study activities 19. Any condition which, in the opinion of the investigator, would prevent the participant from granting informed consent or complying with the protocol, such as dementia, mental illness, or serious systemic medical disease Where potential CSCR participants present with both eyes meeting the above criteria, one eye only will be included in the study. The eye with the greatest central 1 mm subfield thickness (µm) on OCT imaging will be the study eye. In these participants, data on the fellow affected eye in the study will still be collected, to allow the possibility of looking at the symmetry of outcomes between eyes of an individual but will not be included in formal statistical analysis. For non-CSCR participants, only one eye will be included in the study. Where potential non-CSCR participants present with both eyes meeting the above criteria, the study eye will be chosen at random by last digit of their day of birth, with even numbers including 0 corresponding to right eye and odd numbers corresponding to left eye (e.g. DOB 31/12/1960 = left eye).