Clinical Research Directory
Browse clinical research sites, groups, and studies.
Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Corn
Sponsor: North Carolina Agriculture & Technical State University
Summary
The purpose of this research study is to identify biomarkers of whole grain (WG) corn intake following an acute exposure in a pharmacokinetic (how the body absorbs, processes, and gets rid of a substance or ingredient) feeding study. In this aim, investigators will conduct a randomized crossover acute pharmacokinetic study of corn. Investigators will then use a targeted metabolomics approach to identify the exposure markers of corn intake, further develop analytical methods to study its pharmacokinetics, and build our in-house WG metabolite database and an untargeted metabolomics approach to investigate postprandial biomarkers of corn intake. At the completion of this study, our expectation is that investigators will identify corn phytochemicals and its metabolites as objective biomarkers of total and individual WG corn that are commonly consumed by Americans.
Key Details
Gender
All
Age Range
25 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2026-08-04
Completion Date
2026-12-31
Last Updated
2026-08-24
Healthy Volunteers
Yes
Conditions
Interventions
Whole-Grain Corn
Participants will consume two servings of cooked whole-grain corn (46 g raw grain per serving; 92 g total) during the pharmacokinetic study visit.
Refined Corn
Participants will consume two servings of cooked refined corn (46 g raw grain per serving; 92 g total) during the pharmacokinetic study visit.
Locations (1)
Clinical Research Core (CRC)
Kannapolis, North Carolina, United States