Clinical Research Directory

Inclusion Criteria: 1. Adults older than 50 years. 2. Kellgren-Lawrence grade 1 or higher on weight-bearing plain radiographs of the study knee. 3. Osteoarthritis-related pain in the study knee for at least 3 months. 4. Anterior knee pain in the study knee involving the peripatellar, anterior patellar, or retropatellar region, with clear provocation or worsening of anterior knee pain during at least one patellofemoral joint-loading activity: stair ascent or descent, squatting, or rising from a chair. 5. If medial, lateral, or posterior knee pain is also present, the participant is able to distinguish and separately report anterior knee pain. 6. Voluntary written informed consent before study participation. Exclusion Criteria: 1. Acute injury of the study knee within the previous 3 months, including fracture, ligament tear, or meniscal tear requiring surgical treatment or immobilization. 2. Injection therapy to the study knee within the previous 3 months. 3. Current use of opioid analgesics for pain control. 4. Does not own a smartphone or is unable to use the mobile application. 5. Current participation in another clinical trial or planned participation in another clinical trial during this study. 6. Diagnosed active inflammatory arthritis, including rheumatoid arthritis, psoriatic arthritis, or reactive arthritis. 7. Acute attack of gout or pseudogout in the study knee within the previous 3 months. 8. Previous total knee arthroplasty, corrective osteotomy, or other major surgery affecting knee alignment or joint structure in the study knee. 9. Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study.