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Restoring Independence With Stimulation-Enhanced Treatment for People With Functional Neurological Disorder
Sponsor: University of Auckland, New Zealand
Summary
The goal of this clinical trial is to test a new treatment for adults with walking problems due to Functional Neurological Disorder (FND). The main question the trial aims to answer is: \- Is stimulation-enhanced physical therapy an effective treatment for walking problems due to FND? Researchers will compare the stimulation-enhanced physical therapy to gold-standard physical therapy. Participants will: * Complete three in-person sessions on three consecutive days * Complete follow-up assessments by video call at 7 days, 30 days and 90 days after treatment
Official title: A Phase 3, Single-site, Assessor-blinded, Randomised Controlled Trial of Transcranial Magnetic Stimulation-Enhanced Treatment to Restore Movement Agency and Walking Independence in People With Functional Neurological Disorder
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-11
Completion Date
2030-04
Last Updated
2026-08-18
Healthy Volunteers
No
Interventions
Stimulation-Enhanced Physical Therapy
The intervention uses Transcranial Magnetic Stimulation (TMS) to activate the motor pathways from the primary motor cortex to affected lower limb muscles. This is followed by specialist physical therapy applying consensus recommendations for the treatment of movement symptoms due to FND. Key elements include distraction, momentum, and exploratory movement.
Active Comparator
The active comparator uses structured goal-setting and movement imagery to prepare for physical therapy. This is followed by specialist physical therapy applying consensus recommendations for the treatment of movement symptoms due to FND. Key elements include distraction, momentum, and progressive movement retraining.
Locations (1)
Clinical Research Centre, Grafton Campus, University of Auckland
Auckland, Auckland, New Zealand