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School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy
Sponsor: University College Cork
Summary
Neonatal HIE increases the risk for cognitive impairments in childhood. Neonatal MRI brain scans are a strong predictor for outcome, however a normal scan has only a 35% sensitivity and 85% specificity for a normal outcome. This may be explained by variability in the brain's development over time in response to the initial insult. This project will aim to develop a neonatal MRI machine learning algorithm that incorporates both initial injury and radiomic features associated with future brain development (based on school-age MRI) to predict school-age outcome. This will be achieved by conducting a case-control cohort study looking at School-age MRI and outcomes of children with a history of neonatal HIE.
Key Details
Gender
All
Age Range
5 Years - 12 Years
Study Type
OBSERVATIONAL
Enrollment
196
Start Date
2024-03-09
Completion Date
2028-12-31
Last Updated
2026-08-18
Healthy Volunteers
Yes
Conditions
Locations (1)
University College Cork
Cork, Cork, Ireland