Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of BG Versus RI on the Depth of WSL
Sponsor: Riphah International University
Summary
The aim of this in vitro study is to assess the mean lesion depth improvement and hardness of artificial white spot lesions by comparing the effects of bioactive glass toothpaste and resin infiltration (ICON).
Official title: Effect of Bioactive Glass Versus Resin Infiltration (ICON) on the Depth of White Spot Lesions: An in Vitro Study
Key Details
Gender
All
Age Range
15 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-09-01
Completion Date
2027-03-30
Last Updated
2026-08-18
Healthy Volunteers
Yes
Conditions
Interventions
Bioactive Glass (NovaMin)
A carbonated beverage (Coca Cola, Pakistan ltd) will be used for artificial white spot lesion formation. The pH of the beverage will be 4-4.5 at 37ºC. The teeth will be immersed in demineralization solution for 4 weeks before treatment. The solution will be changed every 48 hrs. to keep the pH constant. After demineralization specimens will be washed with distilled deionized water (DDW). The tooth will have a white spot lesion only on the buccal surface. A sufficient amount of 5% bioactive glass (Biomin F T/P) was applied on the tooth surface for three minutes using a tooth brush. The toothpaste remained on the surface for an additional 30 minutes.
Resin Infiltration (ICON)
A carbonated beverage (Coca Cola, Pakistan ltd) was used for artificial white spot lesion formation. The pH of the beverage was 4-4.5 at 37ºC. The teeth were be immersed in demineralization solution for 4 weeks before treatment. The solution was changed every 48 hrs. to keep the pH constant. After demineralization specimens were washed with distilled deionized water (DDW). The tooth would have a white spot lesion only on the buccal surface. Resin infiltration (ICON) infiltration will be applied according to manufacture as following: * Application of Icon Etch (15% HCL gel) for 2 minutes. * Water rinsing and air drying for 30 sec. * Application of Icon-dry (ethanol) for 30 sec. * Air drying * Application of Icon Infiltrant for 3 minutes. * Light curing for 40 seconds.
Fluoride Toothpaste
A carbonated beverage (Coca Cola, Pakistan ltd) was used for artificial white spot lesion formation. The pH of the beverage will be 4-4.5 at 37ºC. The teeth were immersed in demineralization solution for 4 weeks before treatment. The solution was changed every 48 hrs. to keep the pH constant. After demineralization specimens was washed with distilled deionized water (DDW). The tooth would have a white spot lesion only on the buccal surface. The teeth were cleaned and dried first. 5% Sodium fluoride (Enamelist) varnish was applied on tooth surface with disposable tooth brush. The varnish remained undisturbed on teeth for 4 hours.
Locations (1)
Islamic International Dental Hospital
Islamabad, Capital, Pakistan