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Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
Sponsor: Novo Nordisk A/S
Summary
The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo). Results from this study will help select the most optimal lower dose of oral semaglutide that can be used for treating participants living with overweight or obesity.
Official title: Efficacy and Safety of Once Daily Oral Semaglutide in Adults With Overweight or Obesity
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
450
Start Date
2026-08-12
Completion Date
2028-04-11
Last Updated
2026-09-09
Healthy Volunteers
No
Conditions
Interventions
Semaglutide
Participants will receive semaglutide orally.
Placebo
Participants will receive placebo orally.
Locations (62)
Uni of Alabama at Birmingham
Birmingham, Alabama, United States
Headlands Research California, LLC
Escondido, California, United States
National Research Institute - Huntington Park
Huntington Park, California, United States
Los Angeles Institute for Metabolic Research
Los Angeles, California, United States
ERG Holding Company, LLC / Evolution Research Group, LLC
Delray Beach, Florida, United States
ERG Holding Company, LLC / Evolution Research Group, LLC
Fort Myers, Florida, United States
Jedidiah Clinical Research
Tampa, Florida, United States
East West Med Res Inst
Honolulu, Hawaii, United States
L-MARC Research Center
Louisville, Kentucky, United States
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States
Jubilee Clinical Research, Inc.
Las Vegas, Nevada, United States
Corvallis Clinic PC Clinical Research Department
Corvallis, Oregon, United States
UPA Ctr Weight and Eating Dis
Philadelphia, Pennsylvania, United States
Spartanburg Medical Research
Spartanburg, South Carolina, United States
Cedar Health Research
Dallas, Texas, United States
Selma Medical Associates
Winchester, Virginia, United States
Anima Research Center
Alken, Belgium
Imelda
Bonheiden, Belgium
UZ Brussel - Universitair Ziekenhuis Brussel
Brussels, Belgium
Universitair Ziekenhuis Gent
Ghent, Belgium
KORMONT
Kluisbergen, Belgium
AIPSMC - DiMed EOOD
Haskovo, Bulgaria
Medical Center Zdrave Lom EOOD
Lom, Bulgaria
IPMC - Dr. Elizabeta Dimitrova
Petrich, Bulgaria
MHAT Hadzhi Dimitar OOD
Sliven, Bulgaria
DCC Neoklinik EAD
Sofia, Bulgaria
DCC 1 Velingrad EOOD
Velingrad, Bulgaria
Aarhus Universitetshospital, Steno Diabetes Center Aarhus
Aarhus N, Denmark
Gentofte Hospital - Center for Klinisk Metabolisk Forskning
Hellerup, Denmark
Regionshospitalet Gødstrup, Hjertesygdomme
Herning, Denmark
Hôpital Privé Saint Martin_Service de chirurgie digestive
Caen, France
LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service d'endocrinologie
Le Coudray, France
Hôpital Privé La Louvière_Service de chirurgie
Lille, France
CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques
Vénissieux, France
City Hospital Kliniki Monoprosopi I.K.E.
Kalamata, Greece
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
Marousi, Greece
Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
Peristeri, Greece
NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
Thessaloniki, Greece
Thermi Clinic S.A. - Diabetes and Internal Medicine Department
Thessaloniki, Greece
Progress Clinical Research Amsterdam
Amsterdam, Netherlands
Praktijk Dokters van Nederhoven
Zwijndrecht, Netherlands
Progress Clinical Research Zwolle
Zwolle, Netherlands
Kresmed Sp. z o. o.
Bialystok, Poland
Athleticomed Sp. z o.o.
Bydgoszcz, Poland
Gierach-Med
Bygdoszcz, Poland
Santa Sp. z o.o.
Lodz, Poland
Centrum Zdrowia Metabolicznego Paweł Bogdański
Poznan, Poland
Velocity Nova Sp. z o.o.
Staszów, Poland
NBR Polska Tomasz Klodawski
Warsaw, Poland
Care Access Polska Sp. Z o.o.
Warsaw, Poland
FutureMeds Sp. z o.o.
Warsaw, Poland
HU de Fuenlabrada_Endocrinología
Fuenlabrada, Madrid, Spain
CPE Bola Azul_Endocrinología y Nutrición
Almería, Spain
Hosp. Vithas Sevilla_Endocrino y Nutrición
Castilleja de la Cuesta, Spain
Hospital Naval Ferrol
Ferrol, Spain
Clínica Palacios Madrid
Madrid, Spain
Clínica Gaias Santiago
Santiago de Compostela, Spain
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
Seville, Spain
H. Infanta Luisa_Endocrino y Obesidad
Seville, Spain
CTC GoCo Mölndal
Mölndal, Sweden
Enheten för Kliniska Studier (EKS), Örebro
Örebro, Sweden
CTC Stockholm
Stockholm, Sweden