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ACTIVE NOT RECRUITING
NCT07770958

Circadian Disruption And Cardiovascular Risk In Young Adults With Hypertension

Sponsor: Medical University of Sofia

View on ClinicalTrials.gov

Summary

This prospective observational study will investigate whether circadian disruption is associated with higher blood pressure and a less favorable cardiovascular profile in young adults aged 18 to 45 years with essential arterial hypertension. Participants will undergo 14 days of wrist actigraphy using the CamNtech MotionWatch 8, 24-hour ambulatory blood pressure monitoring, cardiovascular assessment, laboratory testing, and validated questionnaires assessing perceived stress and insomnia symptoms. Circadian disruption will be classified using a predefined five-component research index based on actigraphy measures. Participants with three or more abnormal circadian indicators will be classified as Circadian Disruption Index-positive and compared with participants with zero to two abnormal indicators. The primary outcome is mean 24-hour systolic blood pressure. Secondary outcomes include nocturnal blood pressure patterns, cardiac structure and function, heart-rate variability, stress, insomnia symptoms, and individual circadian measures. The Circadian Disruption Index is a study-specific research classification and is not intended to diagnose a circadian rhythm sleep-wake disorder.

Official title: Prospective Observational Study Of Circadian Disruption And Cardiovascular Risk In Young Adults With Arterial Hypertension

Key Details

Gender

All

Age Range

18 Years - 45 Years

Study Type

OBSERVATIONAL

Enrollment

200

Start Date

2023-09-01

Completion Date

2027-05-01

Last Updated

2026-08-19

Healthy Volunteers

No

Locations (1)

UMHAT " Tcaritca Yanna - ISUL"

Sofia, Sofia, Bulgaria