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Circadian Disruption And Cardiovascular Risk In Young Adults With Hypertension
Sponsor: Medical University of Sofia
Summary
This prospective observational study will investigate whether circadian disruption is associated with higher blood pressure and a less favorable cardiovascular profile in young adults aged 18 to 45 years with essential arterial hypertension. Participants will undergo 14 days of wrist actigraphy using the CamNtech MotionWatch 8, 24-hour ambulatory blood pressure monitoring, cardiovascular assessment, laboratory testing, and validated questionnaires assessing perceived stress and insomnia symptoms. Circadian disruption will be classified using a predefined five-component research index based on actigraphy measures. Participants with three or more abnormal circadian indicators will be classified as Circadian Disruption Index-positive and compared with participants with zero to two abnormal indicators. The primary outcome is mean 24-hour systolic blood pressure. Secondary outcomes include nocturnal blood pressure patterns, cardiac structure and function, heart-rate variability, stress, insomnia symptoms, and individual circadian measures. The Circadian Disruption Index is a study-specific research classification and is not intended to diagnose a circadian rhythm sleep-wake disorder.
Official title: Prospective Observational Study Of Circadian Disruption And Cardiovascular Risk In Young Adults With Arterial Hypertension
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2023-09-01
Completion Date
2027-05-01
Last Updated
2026-08-19
Healthy Volunteers
No
Locations (1)
UMHAT " Tcaritca Yanna - ISUL"
Sofia, Sofia, Bulgaria