Clinical Research Directory

Opioid-Free Anesthesia in Colorectal Surgery, 2025 (OFA-CRC-2025)

Sponsor: Hospital Universitario La Fe

Summary

This study wants to find out if using a pain control method without opioids (Opioid-Free Anesthesia or OFA) works as well as or better than standard anesthesia (which uses opioids) for adults having minimally invasive (laparoscopic) colorectal surgery. Opioids are strong pain medicines often used during surgery, but they can cause side effects like nausea, vomiting, slower digestion, and breathing problems. Researchers will divide participants into two groups by chance (like flipping a coin). One group will receive the opioid-free anesthesia, which uses a combination of other types of pain medicines. The other group will receive standard anesthesia with opioids. The main goal is to see if the opioid-free method reduces pain and the need for extra pain medicine in the first 24 hours after surgery. The study will also look at whether patients have fewer side effects, wake up more comfortably, and can leave the hospital sooner.

Official title: Prevention of Acute Postoperative Pain in Laparoscopic Colorectal Surgery: A Comparison Between Opioid-Free Anesthesia and Conventional Strategy as a Method of Intraoperative Analgesia

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