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NOT YET RECRUITING
NCT07771088
NA

Exploring Biological Mechanisms Underlying the TEACH Intervention for Adolescents With Lupus

Sponsor: The Hospital for Sick Children

View on ClinicalTrials.gov

Summary

This study aims to understand how the TEACH program helps improve mental health and well-being in adolescents with childhood-onset lupus. Researchers will examine changes in brain function and inflammation before and after the program and explore how these changes relate to improvements in symptoms such as anxiety, depression, fatigue, and pain. Twenty adolescents with cSLE, aged 12-18 years, will participate by completing the TEACH program, brain imaging, blood tests, and questionnaires.

Key Details

Gender

All

Age Range

12 Years - 18 Years

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2026-12-01

Completion Date

2027-12-31

Last Updated

2026-10-13

Healthy Volunteers

No

Conditions

Interventions

BEHAVIORAL

TEACH

TEACH is a form of cognitive behavioral therapy that has been carefully adapted for adolescents with lupus. It targets common and debilitating symptoms in cSLE, including depression, fatigue, anxiety, and pain. Core components include psychoeducation, activity pacing, cognitive restructuring, relaxation and mindfulness strategies, problem solving, and caregiver-supported skill development. TEACH has previously demonstrated clinical efficacy in reducing depressive symptoms and improving fatigue and anxiety in adolescents with lupus.