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Effects of N-Acyl Taurines on Incretin Levels in Healthy Subjects
Sponsor: University Hospital, Gentofte, Copenhagen
Summary
This study is an investigator-initiated, randomised, double-blind, placebo-controlled, cross-over human trial investigating the effect of arachidonoyl-taurine (C20:4-taurine) and oleoyl-taurine (C18:1-taurine) on GLP-1 secretion during fasting and feeding.
Official title: Effects of N-Acyl Taurines on Incretin Levels in Healthy Subjects: a Randomised, Double-blind, Placebo-controlled, Cross-over Study
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2027-06
Completion Date
2028-12
Last Updated
2026-08-18
Healthy Volunteers
Yes
Conditions
Interventions
Placebo: First dose at 0 hours
Vehicle (ultrapure water with 10 % fish sauce), orally administered
Arachidonoyl-taurine: First dose at 0 hours
Arachidonoyl-taurine (2 mg/kg) dissolved in ultrapure water with 10 % fish sauce, orally administered
Oleoyl-taurine: First dose at 0 hours
Oleoyl-taurine (2 mg/kg) dissolved in ultrapure water with 10 % fish sauce, orally administered
Liquid meal and second dose of placebo at 3 hours
Liquid meal with 1.5 g paracetamol. Administered with a second dose of: Vehicle (ultrapure water with 10 % fish sauce), orally administered
Liquid meal and second dose of OLE-T at 3 hours
Liquid meal with 1.5 g paracetamol. Administered with a second dose of: Oleoyl-taurine (2 mg/kg) dissolved in ultrapure water with 10 % fish sauce, orally administered
Liquid meal and second dose of ARA-T at 3 hours
Liquid meal with 1.5 g paracetamol. Administered with a second dose of: Arachidonoyl-taurine (2 mg/kg) dissolved in ultrapure water with 10 % fish sauce, orally administered