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Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage
Sponsor: LTD "EKODNIPRO", Medical centre Medical Plaza Dnipro
Summary
This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple eggs, but these medications can be very expensive and create a barrier to treatment. This clinical trial tests whether substituting a significant portion of these standard medications with human chorionic gonadotropin (hCG) is just as effective. Researchers will compare the number and quality of eggs and embryos produced by women using the experimental hCG protocol versus those using the standard gonadotropin protocol. The main goal is to determine if the hCG method can provide similar clinical outcomes and safety profiles while significantly reducing the overall financial cost of IVF treatment.
Official title: Prospective Randomized Single-Blind Study of the Effectiveness of the Superovulation Stimulation Protocol Using hCG Compared to Standard Protocols With Different Gonadotropin Doses in In Vitro Fertilization Programs
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
360
Start Date
2026-08-17
Completion Date
2028-05-01
Last Updated
2026-08-27
Healthy Volunteers
No
Conditions
Interventions
Human Chorionic Gonadotropin (hCG)
Administered in sub-trigger doses of 200 IU (without FSH) as a substitute for LH activity and to support folliculogenesis
GnRH antagonist
Administered starting on the 6th day of stimulation as part of a fixed antagonist protocol
Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
Administered to induce final oocyte maturation before retrieval
Gonadotropins (FSH or FSH/LH)
Standard follicle-stimulating hormone (FSH) or FSH/LH preparations administered continuously at doses ranging from 100 to 225 IU/day.
Gonadotropins (FSH or FSH/LH)
Standard follicle-stimulating hormone (FSH) or FSH/LH preparations administered continuously at doses ranging from 100 to 225 IU/day before main cohort of follicles reach size 11-12mm
Locations (3)
Sali international school of fertility medicine
Kampala, Uganda
LTD "Yuzko" Yuzko Medical Center
Chernivtsi, Ukraine
LTD "EKODNIPRO" Medical Centre "Medical Plaza"
Dnipro, Ukraine