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Cross-modal Neuromodulation to Improve Balance and Cognition in Older Adults With Glaucoma: A Randomized Trial of Cerebellar Transcranial Electrical Stimulation
Sponsor: The Hong Kong Polytechnic University
Summary
The goal of this clinical trial is to use different tES techniques to constantly stimulate the cerebellum in older glaucoma patients. The main questions aim to answer : 1. If the different types of tES targeting the cerebellum can modulate glaucoma patients' balance function and visual-cognitive function? 2. Which tES techniques among the two types can benefit most? Participants will be required to receive the stimulation 15 times (3 sessions, 5 continuous days/session, 1-week interval between each session), and complete the balance and visual-cognitive function outcome measurements before and after each session.
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-07-01
Completion Date
2029-11-01
Last Updated
2026-08-18
Healthy Volunteers
No
Conditions
Interventions
transcranial electrial stimulation
This intervention is uniquely designed to enhance balance function in patients with glaucoma using non-invasive cerebellar Transcranial Electrical Stimulation (tES), encompassing both transcranial Direct Current Stimulation (tDCS) and transcranial Alternating Current Stimulation (tACS). Glaucoma-induced visual field loss disrupts the visual feedback critical for postural control, forcing patients to rely heavily on sensory re-weighting (integrating vestibular and proprioceptive inputs). The cerebellum is the central hub for this multi-sensory integration and motor adaptation. By modulating cerebellar excitability and neural oscillations, this intervention aims to facilitate sensory re-weighting, optimize vestibular-ocular/spinal reflexes, and ultimately improve dynamic and static balance.
Locations (1)
Hong Kong Polytechnic University
Kowloon, Hong Kong, Hong Kong