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Prospective Analysis of Blood Flow Restriction Training in Patients With Rheumatoid Arthritis and Psoriatic Arthritis Compared to Conventional Strength Training
Sponsor: University of Bonn
Summary
This single-centre, randomized prospective interventional study assesses the effect of blood flow restriction training in patients with rheumatoid arthritis compared with conventional resistance training. In this prospective pilot study, patients with RA and PsA will be randomized to one of three groups: Kaatsu BFR training, conventional resistance training, or a non-training control group. The training intervention will be performed twice weekly over a 12-week period. Disease activity will be assessed before and after the (non-)training period using the DAS28, PsAID12, Tender Joint Count, Swollen Joint Count, FFB-H-P and IPAQ questionnaires, clinical examination, and C-reactive protein (CRP) levels. In addition, muscle diemeters will be assessed by ultrasound, while body measurements, bioelectrical impedance analysis, and cytokine and myokine levels will also be determined at both time points.
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
102
Start Date
2022-06-18
Completion Date
2024-01-31
Last Updated
2026-08-19
Healthy Volunteers
No
Conditions
Interventions
Blood Flow Restriction Training (BFRT)
This intervention utilizes specialized pressure cuffs to modulate and partially restrict blood flow during exercise. The technique aims to simulate the effects of high-intensity strength training while using low external loads. The cuffs will be adjusted to specific pressure levels suitable for both upper and lower limbs to ensure optimal safety and effectiveness. The primary goal is to improve muscle function and hypertrophy with minimal joint stress in patients with arthritis.
Conventional Strength Training
This intervention involves traditional resistance exercises using progressively increasing weights to achieve muscle strengthening. Participants will engage in exercises targeting major muscle groups under supervised conditions, following standard strength training protocols for arthritis patients to avoid overloading the joints.
Locations (1)
University Hospital Bonn, Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology
Bonn, North Rhine-Westphalia, Germany