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Effects of Hyperbaric Oxygen Combined With Aerobic Exercise on Working Memory Among Stroke Patients
Sponsor: Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University
Summary
This single-center randomized controlled trial enrolled stroke patients with working memory impairment. Participants were randomly divided into the hyperbaric oxygen combined low-intensity focused ultrasound intervention group and the conventional rehabilitation control group. The intervention lasted for a fixed course, and indicators including working memory performance and prefrontal cortex activation detected by fNIRS were compared before and after treatment. The study aims to verify whether combined intervention can better improve cognitive function in stroke survivors. All subjects signed informed consent and obtained ethical approval before enrollment.
Official title: Effects of Combined Hyperbaric Oxygen Therapy and Moderate-Intensity Aerobic Exercise on Working Memory in Stroke Patients: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
65 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-12-06
Completion Date
2025-05-01
Last Updated
2026-08-20
Healthy Volunteers
No
Conditions
Interventions
Conventional rehabilitation therapy
Routine physical rehabilitation including physical factor therapy, occupational therapy and basic motor training, 5 sessions per week, lasting for 14 consecutive days, no additional aerobic exercise or hyperbaric oxygen treatment.
Moderate-intensity aerobic exercise
Sitting stationary bicycle training: 4-minute warm-up, 15-minute moderate-intensity cycling (heart rate controlled at 60%-69% of predicted maximum heart rate), 3-minute relaxation after training; implemented 5 times weekly for 14 days, combined with conventional rehabilitation.
Hyperbaric Oxygen Therapy (HBOT)
90-minute hyperbaric oxygen treatment under 2.0 ATA pressure, patients inhale pure oxygen through facial mask with short air breaks; 5 sessions weekly for 14 days, carried out together with conventional rehabilitation.
Combined aerobic exercise and hyperbaric oxygen therapy
Moderate-intensity aerobic exercise and hyperbaric oxygen therapy are performed sequentially on the same day, combined with conventional rehabilitation, 5 sessions weekly for 14 consecutive days.
Locations (1)
Wuhan Sixth Hospital
Wuhan, Hubei, China