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Efficacy of Bifidobacterium Animalis Subsp. Lactis in the Treatment of Indirect Hyperbilirubinemia in Term Neonates
Sponsor: Can Tho University of Medicine and Pharmacy
Summary
This study aims to evaluate the effectiveness of adjunctive oral Bifidobacterium animalis subsp. lactis in term neonates with indirect hyperbilirubinemia receiving phototherapy. The study will compare the effects of adjunctive probiotics plus standard phototherapy with standard phototherapy alone on the duration of phototherapy, length of hospital stay, serum total bilirubin reduction, phototherapy-related adverse events, and hospital readmission after discharge.
Official title: Efficacy of Bifidobacterium Animalis Subsp. Lactis as an Adjunct to Phototherapy in the Treatment of Indirect Hyperbilirubinemia in Term Neonates
Key Details
Gender
All
Age Range
Any - 28 Days
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-08-01
Completion Date
2028-05-31
Last Updated
2026-08-19
Healthy Volunteers
No
Conditions
Interventions
Bifidobacterium animalis subsp. lactis
Standard phototherapy and oral Bifidobacterium animalis subsp. lactis (1 × 10⁹ CFU/day; 6 drops once daily)
Standard Phototherapy
Standard phototherapy without probiotic supplementation.
Locations (1)
Can Tho University of Medicine and Pharmacy
Can Tho, Vietnam