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Autologous Plasma Rich in Growth Factors for Severe Dry Eye Disease
Sponsor: Gladys Lucia Silva Linares
Summary
The goal of this clinical trial is to evaluate the change in dry eye symptoms after the treatment with Plasma Rich in Growth Factors (PRGF) in patients with severe dry eye. The main question it aims to answer is: Are dry eye simptoms less after the treatment with PRGF? Researchers will compare standard topical treatment and PRGF with standard topical treatment and placebo to see if there is a difference in dry eye symptoms between arms. Secondary outcomes include changes in tear meniscus height, non invasive tear break-up time, conjunctival hyperemia, meibomian gland dropout and Ocular Staining Score (OSS) scale for corneal and conjunctival damage. Participants will be asked to use standard treatment and PRGF or placebo for 1 month.
Official title: Impact of Treatment With Autologous Plasma Rich in Growth Factors (PRGF) in Patients With Severe Dry Eye Disease.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-08-25
Completion Date
2027-08
Last Updated
2026-08-25
Healthy Volunteers
No
Conditions
Interventions
PRGF
PRGF eyedrops four times a day for 1 month
Balanced Salt Solution (BSS®)
Balanced salt solution 0.09% eyedrops four times a day for 1 month