Clinical Research Directory

Inclusion Criteria: * Children aged 6 to 16 years. * Presence of at least one permanent first molar diagnosed with Molar-Incisor * Hypomineralization (MIH), according to the criteria established by the European Academy of Paediatric Dentistry (EAPD). * Deep carious lesion involving the inner third of dentin, confirmed clinically and radiographically. * Diagnosis of symptomatic or asymptomatic irreversible pulpitis based on clinical examination, patient history, and pulp sensibility tests. * Tooth considered restorable after completion of treatment. * Presence of vital pulp tissue confirmed by bleeding following coronal pulp removal. * Child and parent/legal guardian able to understand study procedures and comply with follow-up requirements. * Written informed consent obtained from the parent or legal guardian and assent obtained from the child when applicable. Exclusion Criteria: * Teeth presenting clinical or radiographic signs of pulp necrosis. * Presence of spontaneous swelling, abscess, sinus tract, cellulitis, or other signs of acute odontogenic infection. * Evidence of internal or external root resorption. * Presence of periapical or furcation radiolucency suggestive of endodontic pathology. * Teeth with advanced periodontal disease or pathological mobility. * Teeth with root fractures, crown-root fractures, or extensive structural destruction that precludes definitive restoration. * Teeth in which hemostasis cannot be achieved within the time established by the study protocol after coronal pulp removal. * Children with systemic diseases or medical conditions that may affect healing or interfere with study outcomes. * Current use of medications that may alter pain perception, inflammatory response, or tissue healing. * Previous endodontic treatment or pulp therapy performed on the study tooth. * Inability or unwillingness of the participant or parent/legal guardian to attend follow-up visits.