Clinical Research Directory

Inclusion Criteria: * Female registered nurses aged 25-45 years. * Participants must meet at least one of the following criteria, self-reported presence of at least one target symptom of the trial, including insomnia, daytime fatigue, or difficulty initiating sleep or Pittsburgh Sleep Quality Index (PSQI) score \>7. * Engagement in shift work for at least one month before enrollment, with either ≥ 4 night shifts or ≥32 hours of night-shift work during the preceding month. Exclusion Criteria: * Diagnosed with type 1 or type 2 diabetes mellitus and currently receiving pharmacological treatment. * Diagnosed with clinically thyroid dysfunction, including hyperthyroidism or hypothyroidism, and currently receiving pharmacological treatment. * Diagnosed with Cushing's syndrome, pituitary dysfunction, or other clearly defined endocrine disorders. * Diagnosed with polycystic ovary syndrome (PCOS) and currently receiving pharmacological treatment. * Use of medications that may affect study outcomes, including oral contraceptives, glucose-lowering agents, hormonal medications, hypnotics, lipid-regulating agents, or thyroid hormone preparations, within the past 3 months. * Pregnancy, lactation, or planned pregnancy during the study period. * Confirmed severe organic diseases, such as hepatic or renal insufficiency, cardiovascular disease, or malignancy. * Known allergy to any component of the investigational product. * Use of probiotics, prebiotics, or related traditional Chinese medicine preparations within the past 1 month. * Participation in another clinical trial within the past 3 months. * Planned engagement in vigorous exercise or a weight-management program during the study period. * A previous diagnosis of psychiatric disorders, such as anxiety or depression. * Any condition judged by the investigator to involve communication difficulties, poor compliance, or potential interference with adherence to the study protocol.