Clinical Research Directory

Inclusion Criteria: General criteria: * Female participants aged 18 years or older. * Histologically confirmed invasive breast carcinoma diagnosed by core needle biopsy. * Unifocal and unilateral tumor. * Tumor clearly visible and accessible by ultrasound. * Tumor considered technically suitable for ultrasound-guided cryoablation, with the possibility of achieving adequate ice-ball coverage and safety margins. * No known distant metastatic disease. * Ability to understand the study procedures and provide written informed consent. Cohort A: \- Participants considered unsuitable for breast surgery because of age, comorbidities, or other clinical conditions, or participants who decline surgical treatment after appropriate multidisciplinary evaluation. Cohort B: * Postmenopausal participants with early-stage, low-risk invasive breast cancer. * Invasive tumor preferably 15 mm or smaller. * Hormone receptor-positive (estrogen receptor and/or progesterone receptor positive). * HER2-negative. * Histological grade 1 or 2. * Clinically node-negative disease. * Invasive carcinoma of no special type or another favorable low-risk histological subtype Exclusion Criteria: * Multifocal or multicentric breast cancer. * Bilateral breast cancer requiring treatment. * Tumor not adequately visible or accessible by ultrasound. * Tumor location or anatomy preventing safe cryoablation or achievement of an adequate ablation margin. * Known distant metastatic disease. * HER2-positive invasive breast cancer for Cohort B. * Predominantly extensive intraductal disease or other findings considered unsuitable for cryoablation. * Contraindication to the planned cryoablation procedure. * Inability to provide informed consent or comply with study follow-up.