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Comparative Study of Topical Pentoxifylline Versus Topical 5-Fluorouracil Combined With Microneedling and NB-UVB for Stable Vitiligo
Sponsor: Tanta University
Summary
This randomized, single-blinded clinical trial evaluates the efficacy and safety of topical pentoxifylline compared with topical 5-fluorouracil, both combined with microneedling and narrow-band ultraviolet B (NB-UVB) phototherapy, in patients with stable vitiligo. A total of 42 patients with stable vitiligo received six biweekly microneedling sessions over three months, with concomitant NB-UVB phototherapy twice weekly, followed by a three-month follow-up period. Each patient had three vitiliginous patches allocated to topical pentoxifylline with microneedling, topical 5-fluorouracil with microneedling, or microneedling alone.
Official title: Comparative Study of Topical Pentoxiphylline Versus Topical 5- Fluorouracil Both in Combination With Narrow- Band Ultraviolet B Phototherapy and Microneedling for the Treatment of Vitiligo
Key Details
Gender
All
Age Range
6 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2023-01-01
Completion Date
2025-06-30
Last Updated
2026-08-20
Healthy Volunteers
No
Interventions
Microneedling + topical treatment (PTX 20 mg/ml) followed by NB phototherapy
Microneedling + topical treatment (PTX 20 mg/ml) followed by NB phototherapy
Microneedling + topical treatment (5-FU 5%) followed by NB phototherapy
Microneedling + topical treatment (5-FU 5%) followed by NB phototherapy
Microneedling alone followed by NB phototherapy
Microneedling alone followed by NB phototherapy
Locations (1)
Tanta University Hospitals
Tanta, Egypt