Clinical Research Directory
Browse clinical research sites, groups, and studies.
Prospective Natural History Study of POLG Disease
Sponsor: The POLG Foundation
Summary
The PIONEER study is a prospective, natural history study dedicated to characterizing the clinical progression of POLG-related disorders. The research aims to bridge the gap between genetic diagnosis and drug development by mapping how these rare mitochondrial conditions evolve over time. By observing the disease's natural trajectory through a multi-center approach, The study identifies critical clinical milestones that serve as a foundation for evaluating therapeutic efficacy and future therapeutic interventions
Official title: Global Prospective Natural History Study of POLG Disease
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2026-06-17
Completion Date
2031-06-17
Last Updated
2026-09-15
Healthy Volunteers
No
Conditions
Locations (21)
University of California San Diego
San Diego, California, United States
Children's Hospital Colorado
Aurora, Colorado, United States
Columbia University Irving Medical Center
New York, New York, United States
Akron Children's Hospital
Akron, Ohio, United States
Children's Hospital of Philadelphia-Philadelphia
Philadelphia, Pennsylvania, United States
Baylor Hospital
Dallas, Texas, United States
UTHealth Houston
Houston, Texas, United States
Prince of Wales Hospital, Sydney
Sydney, New South Wales, Australia
Copenhagen University Hospital- Copenhagen
Copenhagen, Capital Region of Denmark, Denmark
Children's Hospital, Helsinki University Hospital-Helsinki
Helsinki, Uusimaa, Finland
Oulu University Hospital-Oulu
Helsinki, Uusimaa, Finland
Maastricht University-Maastricht
Maastricht, Limburg, Netherlands
Oslo University Hospital
Oslo, Oslo, Norway
University Hospital of North Norway - Tromsø
Tromsø, Troms, Norway
St. Olav's Hospital-Trondheim
Trondheim, Trøndelag, Norway
Haukeland University Hospital-Bergen
Bergen, Vestland, Norway
Hospital 12 de Octubre- Madrid
Madrid, Madrid, Spain
Karolinska University Hospital
Solna, Stockholm County, Sweden
The Queen Silvia Children's Hospital, University of Gothenburg
Gothenburg, Västra Götaland County, Sweden
Addenbrooke's Hospital, Cambridge University Hospitals
Cambridge, Cambridgeshire, United Kingdom
Great Ormond Street Hospital
London, Central London, United Kingdom