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Subcutaneous Methadone for Cesarean Analgesia: a Non Inferiority Study Using QoR-10
Sponsor: Clinica Alemana de Santiago
Summary
This study aims to evaluate whether subcutaneous methadone provides postoperative analgesia that is non-inferior to that achieved with intrathecal morphine in women undergoing cesarean delivery under neuraxial anesthesia. The primary outcome will be the quality of postoperative recovery, assessed using the QoR-10 score during the first 24 hours after surgery. Secondary outcomes will include postoperative pain intensity, opioid consumption, incidence of adverse effects, and maternal satisfaction. This trial seeks to determine whether subcutaneous methadone could represent an alternative analgesic strategy within multimodal analgesia protocols for cesarean delivery.
Official title: Subcutaneous Methadone for Cesarean Analgesia: A Non-inferiority Study Using Quality of Recovery -10 Score.
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
128
Start Date
2026-08-21
Completion Date
2027-03-31
Last Updated
2026-08-20
Healthy Volunteers
No
Conditions
Interventions
Methadone 0.15 mg/kg
Subcutaneous methadone administered for postoperative analgesia following cesarean delivery under neuraxial anesthesia.
morphine
Intrathecal morphine administered during neuraxial anesthesia for postoperative analgesia following cesarean delivery.