Clinical Research Directory

Inclusion Criteria Participants must be aged 18 years or older and systemically healthy, with no systemic disease that could directly affect inflammatory status or wound healing. Eligible patients must present with an isolated facial recession greater than 2 mm and less than 5 mm (up to a maximum of 5 mm) on non-molar maxillary teeth, classified as Cairo Type 1 (RT1 = Miller Class I and II), meaning gingival recession without interproximal attachment loss. Patients must have had no previous soft tissue surgery at the surgical site, must demonstrate good oral hygiene (full-mouth bleeding on probing below 10%), and must not have had a soft tissue graft previously harvested from the palatal donor site. Finally, participants must be able to comply with all study-related procedures, including attendance at all follow-up visits. Exclusion Criteria Patients are excluded if they have untreated periodontitis or peri-implantitis, or any systemic disease that could potentially impair wound healing, such as diabetes or connective tissue disorders. Pregnancy or breastfeeding, as well as previous or concurrent use of medications affecting mucosal healing (e.g., steroids or high-dose anti-inflammatory drugs), are also grounds for exclusion. Additional exclusion criteria include coagulation or bleeding disorders, cleft palate, active orthodontic treatment with fixed or removable appliances, a history of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years, and antibiotic therapy within the past 6 months. Patients who have previously had a connective tissue graft harvested from the palatal donor site, or who have undergone any other surgical procedure at the palatal donor or recipient site (e.g., apical resection or crown lengthening), are also excluded.