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Magnesium Sulphate With Atropine and Pralidoxime vs Standard Therapy Alone in Acute Organophosphate Poisoning
Sponsor: Muhammad Aamir Latif
Summary
Pakistan, being a developing country, is one of the regions with the most cases of organophosphate (OP) poisoning/toxicity. MgSO4 is one of the most promising adjunctive treatments that needs to be tested. This study is being carried out with the objective of comparing the 15-day all-cause mortality rate and the total cumulative atropine requirement during hospitalization between patients receiving adjunctive magnesium sulphate with standard therapy and those receiving standard therapy alone.
Official title: Comparison of the Efficacy of Adjunctive Magnesium Sulphate With Standard Atropine and Pralidoxime Therapy vs Standard Therapy Alone in Acute Organophosphate Poisoning
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
38
Start Date
2026-05-10
Completion Date
2026-10-10
Last Updated
2026-08-20
Healthy Volunteers
No
Conditions
Interventions
Atropine plus pralidoxime
Patients will be treated with standard atropine and pralidoxime therapy along with adjunctive MgSO4 (loading dose of 4g in 100ml N/S intravenous infusion over 30 minutes, followed by 1g/hr in 100ml N/S continuous IV infusion for 24 hours).
Atropine and pralidoxime with adjunctive MgSO4
Patients will be treated with standard atropine plus pralidoxime therapy alone.
Locations (1)
Nishtar Hospital/Medical University
Multan, Punjab Province, Pakistan