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NOT YET RECRUITING
NCT07779538
PHASE3

Clinical Trials Comparing Trastuzumab Plus Bevacizumab With Bevacizumab as First-line Maintenance Therapy for Epithelial Ovarian Cancer

Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd.

View on ClinicalTrials.gov

Summary

This trial is a randomized, open-label, positive-controlled, multicenter phase Ib/III clinical trial, divided into two phases. Phase Ib aims to evaluate the safety and tolerability of SHR-A1811 in combination with bevacizumab as first-line maintenance therapy in participants with epithelial ovarian cancer without pathological progression (PD) after first-line platinum-based doublet chemotherapy plus bevacizumab (hereinafter referred to as "platinum-based triple therapy"). Phase III aims to evaluate the efficacy and safety of SHR-A1811 in combination with bevacizumab versus bevacizumab as maintenance therapy in participants with epithelial ovarian cancer without PD after first-line platinum-based triple therapy.

Official title: A Randomized, Open-label, Multicenter Phase Ib/III Clinical Trial Comparing Trastuzumab Plus Bevacizumab With Bevacizumab as First-line Maintenance Therapy for Epithelial Ovarian Cancer

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

420

Start Date

2026-09-01

Completion Date

2030-05-30

Last Updated

2026-08-21

Healthy Volunteers

No

Conditions

Interventions

DRUG

trastuzumab

trastuzumab

DRUG

bevacizumab

bevacizumab

Locations (3)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Zhejiang Cancer Hospital

Zhejiang, Hangzhou, China

Yunnan Cancer Hospital

Yunnan, Kunming, China