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Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patients
Sponsor: Jinnah Hospital
Summary
The goal of this clinical trial is to learn whether intravenous (IV) vitamin B12 works better than oral vitamin B12 to correct vitamin B12 deficiency in adults on maintenance hemodialysis. The main questions it aims to answer are: Does IV vitamin B12 raise blood B12 levels more than oral vitamin B12 over four weeks? Does IV vitamin B12 lead to more patients reaching a normal blood B12 level than oral vitamin B12? Do the two routes differ in their effect on blood counts and nerve-related symptoms such as numbness and tingling? Participants will: Receive either an IV injection of vitamin B12 once a week after their dialysis session, or oral vitamin B12 tablets three times a day, for four weeks Have blood tests for vitamin B12 level and blood count at the start of the study and again at week 5 Be checked for nerve-related symptoms such as numbness and tingling at the start of the study and again at week 5 Researchers will compare IV vitamin B12 to oral vitamin B12 to see which route works better at correcting B12 deficiency in hemodialysis patients.
Official title: Comparison of Efficacy Between Oral Versus Intravenous Vitamin B12 Replacement Among Vitamin B12-Deficient Hemodialysis Patients: A Quasi-Experimental Study
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-02-22
Completion Date
2026-07-15
Last Updated
2026-08-24
Healthy Volunteers
No
Interventions
Mecobalamin IV Injection
Mecobalamin (methylcobalamin) 1000 µg/mL ampoule, diluted in 10 mL of 0.9% sodium chloride and administered intravenously as a slow push over 3-5 minutes, once weekly for 4 weeks, via the venous port of the extracorporeal circuit at the end of the hemodialysis session. Ampoules were protected from light until administration. Distinguished from the oral intervention below by route, dose, and frequency.
Mecobalamin Tablets
Mecobalamin (methylcobalamin) 500 µg tablet, taken orally three times daily (total 1500 µg/day) for 4 weeks. Adherence reinforced at each dialysis visit and verified by pill count. Distinguished from the intravenous intervention above by route, dose, and frequency.
Locations (1)
Jinnah Hospital Lahore
Lahore, Punjab Province, Pakistan