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NOT YET RECRUITING
NCT07781696
NA

CnF-DBS for Levodopa-Resistant FOG

Sponsor: Iahn Cajigas

View on ClinicalTrials.gov

Summary

The purpose of this trial is to study the safety, practicality, and effectiveness of deep brain stimulation (DBS) therapy in a brain region called the cuneiform nucleus (CnF) to treat disabling freezing of gait (FOG) in patients with Parkinson's disease (PD) when standard treatments are no longer effective. The study uses either the Medtronic's Percept™ PC or RC systems for DBS therapy. Please note that although the Medtronic systems are FDA-approved for other diseases, they have not been approved for the treatment of FOG in PD and their use for stimulation of the CnF target is experimental.

Official title: Deep Brain Stimulation of the Cuneiform Nucleus for Levodopa-Resistant Freezing of Gait in Parkinson's Disease

Key Details

Gender

All

Age Range

35 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

18

Start Date

2026-09

Completion Date

2028-08

Last Updated

2026-08-24

Healthy Volunteers

No

Interventions

DEVICE

Active Stimulation

Active CnF DBS will be delivered using predefined stimulation parameter ranges considered potentially therapeutic based on prior preclinical and clinical data.

DEVICE

Sham (No Treatment)

Control (sham or sub-therapeutic) stimulation will consist of stimulation settings expected to have no or minimal physiological effect (e.g., stimulation off or amplitude below a predefined threshold).

Locations (3)

University of California San Francisco (UCSF)

San Francisco, California, United States

University of Miami

Miami, Florida, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States