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Multi-Strain Probiotic Supplementation, Salivary Immunity, and Upper Respiratory Symptoms in Trained Athletes
Sponsor: University of Ulster
Summary
This completed external pilot study assessed the feasibility of conducting a randomised, double-blind, placebo-controlled trial of four-week multi-strain probiotic supplementation in trained athletes. Participants were allocated to receive either one probiotic capsule containing 20 billion colony-forming units or a matched rice-flour placebo capsule daily for 28 days. Feasibility measures included recruitment, retention, supplementation adherence and completion of daily monitoring records. Preliminary biological and symptom outcomes included salivary secretory immunoglobulin A and upper respiratory symptom burden. The findings were intended to inform the design of a future definitive randomised controlled trial and were not intended to provide a definitive assessment of efficacy.
Official title: A Randomized, Double-Blind, Placebo-Controlled Study Exploring the Impact of Multi-Strain Probiotic Supplementation on Mucosal Immunity and Upper Respiratory Symptom Episodes in Team-Sport Athletes
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2025-05-13
Completion Date
2025-12-19
Last Updated
2026-08-24
Healthy Volunteers
Yes
Interventions
Multi-Strain Probiotic
One oral capsule was taken daily for 28 days. Each capsule provided 20 billion colony-forming units and contained Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium lactis Bl-04, Bifidobacterium lactis Bi-07, and Bifidobacterium bifidum Bb-02
Rice Flour Placebo
One visually matched oral capsule containing rice flour and no live microorganisms was taken daily for 28 days.
Locations (1)
Ulster University Belfast Campus, Human Physiology Laboratory, Room BC-04-409
Belfast, Northern Ireland, United Kingdom