Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
COMPLETED
NCT07782983
NA

Multi-Strain Probiotic Supplementation, Salivary Immunity, and Upper Respiratory Symptoms in Trained Athletes

Sponsor: University of Ulster

View on ClinicalTrials.gov

Summary

This completed external pilot study assessed the feasibility of conducting a randomised, double-blind, placebo-controlled trial of four-week multi-strain probiotic supplementation in trained athletes. Participants were allocated to receive either one probiotic capsule containing 20 billion colony-forming units or a matched rice-flour placebo capsule daily for 28 days. Feasibility measures included recruitment, retention, supplementation adherence and completion of daily monitoring records. Preliminary biological and symptom outcomes included salivary secretory immunoglobulin A and upper respiratory symptom burden. The findings were intended to inform the design of a future definitive randomised controlled trial and were not intended to provide a definitive assessment of efficacy.

Official title: A Randomized, Double-Blind, Placebo-Controlled Study Exploring the Impact of Multi-Strain Probiotic Supplementation on Mucosal Immunity and Upper Respiratory Symptom Episodes in Team-Sport Athletes

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

15

Start Date

2025-05-13

Completion Date

2025-12-19

Last Updated

2026-08-24

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Multi-Strain Probiotic

One oral capsule was taken daily for 28 days. Each capsule provided 20 billion colony-forming units and contained Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium lactis Bl-04, Bifidobacterium lactis Bi-07, and Bifidobacterium bifidum Bb-02

DIETARY_SUPPLEMENT

Rice Flour Placebo

One visually matched oral capsule containing rice flour and no live microorganisms was taken daily for 28 days.

Locations (1)

Ulster University Belfast Campus, Human Physiology Laboratory, Room BC-04-409

Belfast, Northern Ireland, United Kingdom