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Rapid Rehydration for Severe Hypernatremia
Sponsor: Columbia University
Summary
The goal of this study is to show the feasibility of rapid identification, consenting, randomization, treatment, and follow-up of patients with severe hypernatremia (Na ≥ 155 mEq/L). The investigators plan to randomize 80 patients with severe hypernatremia to rapid hydration (aiming for a correction rate of 18m Eq/L/24h) versus standard of care therapy. The aim of this study is to show the feasibility of the proposed protocol and to collect preliminary safety and efficacy data to inform a subsequent multicenter RCT powered to assess the effect of rapid hydration of patients with severe hypernatremia on 30-day survival.
Official title: Rapid Rehydration in the Treatment of Severe Hypernatremia
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-10
Completion Date
2029-05
Last Updated
2026-08-24
Healthy Volunteers
No
Conditions
Interventions
Intravenous Dextrose 5% solution
sterile solution of glucose and water
Locations (1)
Columbia University Irving Medical Center / New-York Presbyterian
New York, New York, United States