Clinical Research Directory

Inclusion Criteria: 1. Participants with Bipolar Disorder: * Age 25 to 35 years. * Male or female; female participants must be in the mid-luteal phase of the menstrual cycle. * Clinical presentation consistent with a diagnosis of Bipolar I Disorder or Bipolar II Disorder. * First diagnosis of Bipolar Disorder with no previous psychopharmacological treatment (drug-naive), or absence of psychopharmacological treatment for at least 6 months (drug-free). * Ability and willingness to provide written informed consent. 2. Healthy Controls Group: * Age 25 to 35 years. * Male or female; female participants must be in the mid-luteal phase of the menstrual cycle. * No current treatment with psychotropic medications. * No clinical or symptomatic evidence supporting a diagnosis of Bipolar I Disorder or Bipolar II Disorder. * Hamilton Depression Rating Scale (HAM-D) score \<8. * Mania Rating Scale (MRS) score \<11. * No major stressful life events during the previous 6 months, such as bereavement, traumatic events, or divorce. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Current treatment with corticosteroids, immunosuppressive agents, antibiotics, or hormone replacement therapy. * Relevant current medical comorbidities, including autoimmune diseases or other clinically significant internal medicine conditions. * Relevant psychiatric comorbidities. * Current psychopharmacological treatment or psychopharmacological treatment discontinued less than 6 months before enrollment.