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Genistein for the Reduction of Adverse Cardiovascular Events (GRACE)
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Summary
People living with HIV (PLHIV) live longer because of modern HIV medicines, but even with these treatments, their bodies are more inflamed. Long term inflammation increases the risk of heart disease, chronic pain, lung disease, dementia, arthritis, and other infections. Because some anti-inflammatory medicines can cause serious side effects, interact with HIV drugs, or be costly, safer and more affordable treatment options are needed. Genistein is a natural compound found in soy foods. It is considered safe and has been shown to reduce inflammation and improve blood vessel health. This study will test whether genistein can lower inflammation in the blood, improve blood vessel health, and reduce pain in PLHIV.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-09-30
Completion Date
2028-06-30
Last Updated
2026-08-25
Healthy Volunteers
No
Interventions
Genistein (Unconjugated Isoflavones 100)
Genistein: 500 mg twice a day (1000 mg total) for 12 weeks, followed by a washout for 6 weeks
Placebo
Placebo: twice a day (1000 mg total) for 12 weeks, followed by a washout for 6 weeks
Locations (1)
London Regional Health Science Centre
London, Ontario, Canada