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Clinical Utility of Urinary N-Acetyl-β-D-Glucosaminidase (NAG), Kidney Injury Molecule-1 (KIM-1), and Diffusion-Weighted Renal MRI for the Early Detection of Sickle Cell Nephropathy in Children
Sponsor: Assiut University
Summary
To evaluate the diagnostic performance of urinary N-acetyl-β-D-glucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) Biomarkers for detection of early onset of Sickle Cell Nephropathy in children under HU therapy
Key Details
Gender
All
Age Range
4 Years - 18 Years
Study Type
OBSERVATIONAL
Enrollment
90
Start Date
2026-10-01
Completion Date
2027-12-01
Last Updated
2026-08-25
Healthy Volunteers
Yes
Conditions
Interventions
Hydroxy Urea
* Assessment of the diagnostic performance of urinary N-acetyl-β-D-glucosaminidase (NAG) and Kidney Injury Molecule-1 (KIM-1) for early detection of early onset of sickle cell nephropathy in children with sickle cell disease on regular hydroxyurea * Assessment of renal diffusion MRI parameters (DWI/DTI), particularly fractional anisotropy (FA), in children with sickle cell disease.
Locations (1)
Assiut University
Asyut, Egypt