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Curcumin Versus Ibuprofen for Exercise-Induced Muscle Damage in Physically Active Women
Sponsor: University of Valladolid
Summary
xercise-induced muscle damage (EIMD) is a common consequence of unaccustomed or high-intensity exercise and is characterized by muscle soreness, impaired physical performance, inflammation, oxidative stress, and increased circulating biomarkers of muscle damage. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are frequently used to alleviate these symptoms, although their repeated use may be associated with adverse effects. Curcumin, a natural polyphenol with antioxidant and anti-inflammatory properties, has emerged as a potential nutritional strategy to support post-exercise recovery. This randomized, double-blind, placebo-controlled trial aims to compare the effects of oral curcumin supplementation and ibuprofen administration on exercise-induced muscle damage in physically active women. The study evaluates clinical outcomes, physical performance, biomarkers of muscle damage, inflammation, oxidative stress, and other health-related biomarkers to determine whether curcumin may represent a safe and effective nutritional alternative for promoting recovery after eccentric exercise.
Official title: Comparative Efficacy of Oral Curcumin Supplementation Versus Ibuprofen on Exercise-Induced Muscle Damage, Inflammation, Oxidative Stress, and Sports Performance in Physically Active Women: A Randomized Double-Blind Placebo-Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-01-31
Completion Date
2026-08-01
Last Updated
2026-08-25
Healthy Volunteers
Yes
Conditions
Interventions
Curcumin
Participants received oral curcumin supplementation according to the study protocol before and after the eccentric exercise protocol. Curcumin was administered at the predefined dose and duration specified in the protocol. The intervention aimed to evaluate its effects on exercise-induced muscle damage, inflammation, oxidative stress, antioxidant defense, physical performance, and recovery in physically active women.
Ibuprofen
Participants received oral ibuprofen according to the study protocol before and after the eccentric exercise protocol. Ibuprofen was administered at the predefined dose and duration specified in the protocol and served as the active comparator for evaluating recovery following exercise-induced muscle damage.
Placebo
Participants received placebo capsules identical in appearance, packaging, and administration schedule to the active interventions. The placebo contained inert ingredients and was administered according to the study protocol before and after the eccentric exercise protocol.
Locations (1)
University Campus of Soria
Soria, Spain