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Bone Marrow Aspirate Concentrate With Bovine Bone Graft for Unilateral Alveolar Cleft Reconstruction
Sponsor: Tanta University
Summary
This randomized clinical trial evaluated whether adding autologous bone marrow aspirate concentrate (BMAC) to a bovine-derived bone graft improves healing and bone regeneration in patients undergoing reconstruction of a unilateral alveolar cleft. Sixteen participants were randomly assigned in a 1:1 ratio to receive either bovine bone graft combined with BMAC or bovine bone graft alone. Participants were followed for 6 months. Clinical assessments included postoperative pain, soft-tissue healing, fistula recurrence, and tooth eruption. Radiographic assessments included alveolar bone level, CT-derived graft radiodensity, and three-dimensional volumetric measurements of graft integration, resorption, and defect fill.
Official title: Evaluation of Bone Marrow Aspirate Concentrate Combined With Bovine Bone Graft for Unilateral Alveolar Cleft Repair (A Randomized Controlled Clinical Trial)
Key Details
Gender
All
Age Range
7 Years - 25 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2025-03-01
Completion Date
2026-06-16
Last Updated
2026-08-25
Healthy Volunteers
No
Conditions
Interventions
BMAC-Enriched Bovine Bone Grafting
Autologous bone marrow aspirate concentrate (BMAC) was prepared from bone marrow aspirated from the anterior iliac crest and combined with bovine-derived particulate bone graft. BMAC was mixed with the graft at a ratio of 1 mL per 1 cc approximately 10 minutes before implantation into the alveolar cleft defect.
Bovine Bone Grafting
The unilateral alveolar cleft defect was reconstructed using bovine-derived particulate bone graft without the addition of BMAC.
Locations (1)
Faculty of Dentistry, Tanta University
Tanta, Gharbia Governorate, Egypt