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Thiamine, Ascorbic Acid, and Their Combination on MMP-9/TIMP-1 and Inflammatory Balance in Sepsis
Sponsor: Universitas Sumatera Utara
Summary
This two-center, open-label randomized controlled trial evaluated the effect of adjunctive thiamine, ascorbic acid, and their combination compared with 0.9% saline on the extracellular matrix-remodeling axis (matrix metalloproteinase-9 \[MMP-9\] and tissue inhibitor of metalloproteinase-1 \[TIMP-1\]) and the inflammatory-balance axis (interleukin-6 \[IL-6\] and interleukin-10 \[IL-10\]) in adult patients with sepsis. Serum biomarkers were measured by ELISA at baseline and after 72 hours and related to organ dysfunction (SOFA score), acute kidney injury, and in-hospital mortality.
Official title: The Effect of Thiamine, Ascorbic Acid, and Their Combination on Matrix Metalloproteinase-9 (MMP-9), Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), and Inflammatory Balance (IL-6/IL-10) in Adult Sepsis Patients: A Two-Center Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2020-04-01
Completion Date
2021-05-01
Last Updated
2026-08-26
Healthy Volunteers
No
Conditions
Interventions
Thiamine
Thiamine 200 mg IV, over 60 minutes every 12 hours for 3 days.
Ascorbic Acid Injectable Product
Ascorbic acid + Combination (thiamine + ascorbic acid)
Normal Saline 0.9% Injectable Solution
Control (normal saline)
Locations (2)
Haji Adam Malik General Hospital
Medan, North Sumatra, Indonesia
Universitas Sumatera Utara
Medan, North Sumatra, Indonesia