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Seaweed Extract (Fucoidan) for Gut Inflammation in Ulcerative Colitis
Sponsor: Allama Iqbal Medical College
Summary
What is the research question being addressed? Does combining Turbinaria ornata-derived fucoidan with standard therapy lead to a significantly higher rate of gut health restoration-defined by increased fecal short-chain fatty acid (butyrate/acetate) levels, reduced fecal calprotectin, and improved stool consistency-compared to standard therapy alone in Ulcerative Colitis patients? Type of study: Interventional Study design: Randomized controlled trial Masking: Participants Control: Placebo Assignment: Parallel Purpose: Other Adjuvant / Add-On Therapy (Complementary Prebiotic Strategy) Study Phase: Phase1
Official title: Effects of Brown Algae (Turbinaria Ornata) Derived Fucoidan on Intestinal Inflammation and Gut Health in Ulcerative Colitis Patients
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-08
Completion Date
2027-12
Last Updated
2026-08-26
Healthy Volunteers
No
Conditions
Interventions
Low molecular weight fucoidan and standard care
LMWF + 5-ASA Arm Oral administration of 85% purified, dehydrogenated low-molecular-weight fucoidan (\<40 kDa) at a weight-based dose (35 mg/kg/day for active flare) as an adjuvant to standard-of-care 5-aminosalicylate therapy.
Placebo and standard of care
placebo and 5 Aminosalicylic acid
Locations (1)
Allama Iqbal Medical college
Lahore, Punjab Province, Pakistan