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NOT YET RECRUITING
NCT07787182
PHASE1

A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The purpose of this study is to see how safe LY4405094 is and to see how much and how quickly LY4405094 gets into the bloodstream. For healthy participants, the study also looks at how much LY4405094 gets into the fluid around the brain and lasts up to 13 weeks and will include a 4-day stay in the Clinical Research Unit (CRU). For participants with Alzheimer's Disease, the study will also look at levels of a specific Alzheimer's-related protein in the brain and will last up to 25 weeks and will include a 3-day stay in the CRU.

Official title: A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease

Key Details

Gender

All

Age Range

18 Years - 85 Years

Study Type

INTERVENTIONAL

Enrollment

68

Start Date

2026-09

Completion Date

2028-01

Last Updated

2026-08-26

Healthy Volunteers

Yes

Interventions

DRUG

LY4405094

Administered intravenously (IV)

DRUG

LY4405094

Administered Subcutaneously (SC)

DRUG

Placebo

Administered IV

DRUG

Placebo

Administered SC

OTHER

Florbetapir F18

Administered IV

OTHER

Florbetaben F 18

Administered IV

Locations (10)

Irvine Clinical Research

Irvine, California, United States

Fortrea Clinical Research Unit

Daytona Beach, Florida, United States

K2 Medical Research - The Villages

Lady Lake, Florida, United States

K2 Medical Research

Maitland, Florida, United States

Charter Research

Orlando, Florida, United States

Progressive Medical Research

Port Orange, Florida, United States

K2 Medical Research - Tampa

Tampa, Florida, United States

Charter Research

The Villages, Florida, United States

Accel Research Sites - NeuroStudies Clinical Research Unit

Decatur, Georgia, United States

QUEST Research Institute

Farmington Hills, Michigan, United States