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A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease
Sponsor: Eli Lilly and Company
Summary
The purpose of this study is to see how safe LY4405094 is and to see how much and how quickly LY4405094 gets into the bloodstream. For healthy participants, the study also looks at how much LY4405094 gets into the fluid around the brain and lasts up to 13 weeks and will include a 4-day stay in the Clinical Research Unit (CRU). For participants with Alzheimer's Disease, the study will also look at levels of a specific Alzheimer's-related protein in the brain and will last up to 25 weeks and will include a 3-day stay in the CRU.
Official title: A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
68
Start Date
2026-09
Completion Date
2028-01
Last Updated
2026-08-26
Healthy Volunteers
Yes
Interventions
LY4405094
Administered intravenously (IV)
LY4405094
Administered Subcutaneously (SC)
Placebo
Administered IV
Placebo
Administered SC
Florbetapir F18
Administered IV
Florbetaben F 18
Administered IV
Locations (10)
Irvine Clinical Research
Irvine, California, United States
Fortrea Clinical Research Unit
Daytona Beach, Florida, United States
K2 Medical Research - The Villages
Lady Lake, Florida, United States
K2 Medical Research
Maitland, Florida, United States
Charter Research
Orlando, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
K2 Medical Research - Tampa
Tampa, Florida, United States
Charter Research
The Villages, Florida, United States
Accel Research Sites - NeuroStudies Clinical Research Unit
Decatur, Georgia, United States
QUEST Research Institute
Farmington Hills, Michigan, United States