Clinical Research Directory

Photobiomodulation on NMES-Induced Muscle Fatigue and Damage: A Pilot Study

Sponsor: Federal University of Rio Grande do Sul

Summary

Neuromuscular electrical stimulation (NMES) is an effective tool for muscle strengthening and rehabilitation, but its clinical application is often limited by rapid neuromuscular fatigue, muscle discomfort, and potential muscle damage. Photobiomodulation therapy (PBMT) using low-level lasers or LEDs has been proposed as an ergogenic and protective modality capable of attenuating exercise-induced muscle fatigue and damage. However, evidence regarding the acute preventive effects of PBMT on NMES-induced fatigue and muscle damage in humans remains limited and conflicting. The purpose of this randomized, sham-controlled, crossover pilot trial was to evaluate the acute effects of PBMT applied prior to an NMES-induced fatigue protocol on knee extensor neuromuscular fatigability, muscle damage, discomfort, and functional performance in healthy young individuals. Healthy participants had both lower limbs randomized to receive either active PBMT (810 nm, 240 J total per limb across 8 points) or sham PBMT 5 minutes prior to an NMES fatigue protocol (20 minutes of evoked isometric contractions at 20% of maximal voluntary contraction). Primary and secondary outcomes-including maximal voluntary isometric contraction (MVIC) torque, supramaximal twitch torque, muscle damage via ultrasound echointensity (rectus femoris and vastus lateralis), pain pressure thresholds (algometry), visual analog scale (VAS) for discomfort, and functional tests (Single Hop Test and stair ascent/descent)-were assessed at baseline, immediately post-fatigue, and at 24, 48, and 72 hours post-intervention.

Official title: EFEITOS DA FOTOBIOMODULAÇÃO E DOS SÍTIOS DE ESTIMULAÇÃO SOBRE A FADIGA E DANO MUSCULAR INDUZIDOS POR ESTIMULAÇÃO ELÉTRICA NEUROMUSCULAR EM INDIVÍDUOS SAUDÁVEIS

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