Clinical Research Directory

Inclusion Criteria: * Aged 18-40 years * Singleton, healthy pregnancy * Presenting to the Obstetrics and Gynecology outpatient clinic during the first trimester (weeks 8-12) * No history of systemic rheumatic disease, chronic pain syndrome, or serious psychiatric illness * No prior orthodontic treatment * Written informed consent after being informed about the purpose and scope of the study Exclusion Criteria: * Prior treatment for temporomandibular disorders (splint, botulinum toxin, surgery, etc.) * History of maxillofacial trauma or temporomandibular joint surgery * Systemic rheumatic disease, connective tissue disease, or chronic pain syndrome * Use of systemic corticosteroids or hormone replacement therapy * Pregnancy achieved through assisted reproductive techniques (e.g., IVF) * Refusal to consent to blood sampling or questionnaire administration * Language barrier preventing understanding and completion of Turkish-language questionnaires