Clinical Research Directory

Inclusion Criteria: * Women aged from 18 to 75 years * Having been victim of severe violence (rape, sexual assault, physical assault) Currently suffering from PTSD related to the traumatic event. The diagnosis of PTSD is made according to the DSM-5 criteria by a psychiatrist/psychologist using the CAPS-5, regardless of the traumatic event meeting criterion A of the DSM-5, with or without dissociative symptoms as described in the "With dissociative symptoms" section of the DSM-5, Immediate or delayed PTSD CAPS-5 total score ≥ 33 heart rate ≥ 55 bpm * The subject must have signed the consent form. * The subject must be enrolled in a social security program. * The participant must be able to understand and read French. * The participant agrees to comply with the contraception requirements outlined in the protocol. Exclusion Criteria: * Systolic blood pressure below 100 mm Hg. * Contraindications to the administration of propranolol: Asthma, Chronic obstructive pulmonary disease, Decompensated heart failure, Cardiogenic shock, Unpaced second-degree atrioventricular block, Unpaced third-degree atrioventricular block, Spasmodic angina, Uncompensated sinus node dysfunction, bradycardia, Raynaud's syndrome, severe peripheral circulatory disorder, untreated pheochromocytoma, arterial hypotension, hypersensitivity to beta-blockers, history of anaphylactic allergic reaction. * Heart failure (compensated or decompensated) * Severe liver disease * Significant renal impairment * Myasthenia gravis * Personal or family history of psoriasis * Patients who have suffered a head injury within the past year or who have clinical symptoms and residual neurological sequelae * Wearing contact lenses * Severe psychiatric disorders: Severe symptoms of other anxiety disorders, severe symptoms of Obsessive-Compulsive Disorder, history of or current psychotic disorder, bipolar mood disorder, severe personality disorder, alcohol or other substance use disorder * "Yes" response to item 4 of the C-SSRS: active suicidal ideation with intent to act, without a specific plan, and/or "Yes" response to item 5 of the C-SSRS: active suicidal ideation with a specific plan and intent to act * Hospitalized or treated for suicidal behavior within the past 3 months * Previous intolerance to a beta-blocker. * Women of childbearing age not using contraception. * Pregnancy, breastfeeding. * Current use of a beta-blocker, regardless of the formulation. * Known interactions with Propranolol (combination use not recommended and combinations to be used with caution) as indicated in the summary of product characteristics. * Undergoing psychotherapy or pharmacological treatment with psychotropic agents such as antidepressants, neuroleptics, and/or mood stabilizers. However, these subjects may be included after a 2-week therapeutic abstinence period (6 weeks for treatment with fluoxetine). * Patients under judicial protection, under guardianship or curatorship, individuals under family authorization, or under a future protection order with representation regarding the person * Participants who are related to a person involved in the study at the investigator's center, within the clinical research organization (CRO), or at the sponsor * Participation in another interventional research study, clinical trial, or clinical investigation within the 6 months preceding selection