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A Study to Learn About the Study Medicine Called PF-08653944 Taken Once-Weekly Compared to Placebo in Chinese Adults With Overweight or Obesity
Sponsor: Pfizer
Summary
Overweight and obesity are long-term health conditions that can increase the risk of serious health problems, including heart disease, type 2 diabetes, and other medical conditions. The purpose of this study is to learn whether berobenatide is safe and effective for adults in China who have overweight or obesity. Researchers will compare berobenatide with a placebo, which looks like the study treatment but does not contain active medicine. People may be able to participate if they are adults with obesity or if they have overweight together with certain weight-related health conditions. Some participants may also have type 2 diabetes. Specific eligibility requirements will be reviewed by the study doctor before enrollment. Participants will be randomly assigned to receive either berobenatide or placebo. The study treatment will be administered according to the study protocol, and participants will be monitored throughout the study to assess changes in body weight and overall health, as well as any side effects that may occur. During participation, participants will attend study visits and complete study-related assessments. Researchers will collect information about participants' health, body weight, and safety throughout the study. Details about the number of visits, study duration, and study procedures will be explained by the study team before participation. The information learned from this study may help researchers better understand whether berobenatide could be a treatment option for adults living with overweight or obesity.
Official title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ONCE-WEEKLY PF-08653944 IN CHINESE ADULTS WITH OVERWEIGHT OR OBESITY
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2026-09-01
Completion Date
2028-05-23
Last Updated
2026-09-04
Healthy Volunteers
No
Conditions
Interventions
Berobenatide
Solution for injection
Placebo
Solution for injection
Locations (33)
The Second People's Hospital of Hefei
Hefei, Anhui, China
Peking University People's Hospital
Beijing, Beijing Municipality, China
Beijing Friendship Hospital
Beijing, Beijing Municipality, China
Beijing Pinggu Hospital
Beijing, Beijing Municipality, China
Beijing Tsinghua Changgung Hospital
Beijing, Beijing Municipality, China
Chongqing People's Hospital
Chongqing, Chongqing Municipality, China
Chongqing University Three Gorges Hospital
Chongqing, Chongqing Municipality, China
Huizhou Central People's Hospital
Huizhou, Guangdong, China
Harrison International Peace Hospital
Hengshui, Hebei, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The Fourth Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Luoyang First People's Hospital
Luoyang, Henan, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, Henan, China
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Shiyan Taihe Hospital
Shiyan, Hubei, China
Wuhan Third Hospital
Wuhan, Hubei, China
Changzhou Second People's Hospital
Changzhou, Jiangsu, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Nanjing First Hospital
Nanjing, Jiangsu, China
Affiliated Hospital of Nantong University
Nantong, Jiangsu, China
Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, China
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, China
Pingxiang People's Hospital
Pingxiang, Jiangxi, China
The Second Hospital of Jilin University
Changchun, Jilin, China
The First Affiliated Hospital of Xi'an Medical University
Xi'an, Shaanxi, China
Jinan Central Hospital
Jinan, Shandong, China
Zhongshan Hospital,Fudan University
Shanghai, Shanghai Municipality, China
Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
The Fifth People's Hospital of Shanghai
Shanghai, Shanghai Municipality, China
Pudong New Area People's Hospital Shanghai
Shanghai, Shanghai Municipality, China
Hangzhou First People's Hospital
Hangzhou, Zhejiang, China
The first affiliated hospital of Ningbo university
Ningbo, Zhejiang, China
Tianjin Medical University General Hospital
Tianjin, China