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RECRUITING
NCT07793006
NA

New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease

Sponsor: Indiana University

View on ClinicalTrials.gov

Summary

Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.

Key Details

Gender

All

Age Range

1 Year - Any

Study Type

INTERVENTIONAL

Enrollment

500

Start Date

2025-03-17

Completion Date

2028-12

Last Updated

2026-08-28

Healthy Volunteers

No

Interventions

PROCEDURE

Lymph Node or Core Needle Biopsy

DNA isolation to be tested by nucleic acid amplification using the TINY device

PROCEDURE

Fine Needle Aspiration

The sample will be eluted into two tubes, one for Gene Xpert testing and one for storage for EBV and KSHV testing by qPCR and TINY.

DIAGNOSTIC_TEST

Tiny Isothermal Nucleic acid Amplification System (TINY)

Tiny Isothermal Nucleic acid Amplification System (TINY)

Locations (1)

Lighthouse Trust HIV Centers of Excellence

Lilongwe, Malawi