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New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease
Sponsor: Indiana University
Summary
Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.
Key Details
Gender
All
Age Range
1 Year - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2025-03-17
Completion Date
2028-12
Last Updated
2026-08-28
Healthy Volunteers
No
Conditions
Interventions
Lymph Node or Core Needle Biopsy
DNA isolation to be tested by nucleic acid amplification using the TINY device
Fine Needle Aspiration
The sample will be eluted into two tubes, one for Gene Xpert testing and one for storage for EBV and KSHV testing by qPCR and TINY.
Tiny Isothermal Nucleic acid Amplification System (TINY)
Tiny Isothermal Nucleic acid Amplification System (TINY)
Locations (1)
Lighthouse Trust HIV Centers of Excellence
Lilongwe, Malawi