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IBI3042 Study in Healthy Participants and Overweight or Obese Participants
Sponsor: Innovent Biologics (Suzhou) Co. Ltd.
Summary
This is a Phase 1 study of IBI3042, an investigational oral medicine being developed as a potential treatment for overweight and obesity. The study has two parts. Part A will evaluate single doses of IBI3042 in healthy adults. Part B will evaluate repeated doses for 13 weeks in adults with overweight or obesity. The main goal is to assess the safety and tolerability of IBI3042. The study will also evaluate how IBI3042 is processed in the body and explore its effects on body weight and other metabolic measures. Some participants will receive placebo, and some Part B groups will also receive orforglipron for comparison.
Official title: A Phase I Study to Evaluate Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of Single-Dose IBI3042 in Healthy Participants and Multiple-Dose IBI3042 in Overweight or Obese Participants
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
104
Start Date
2026-09-07
Completion Date
2028-01-26
Last Updated
2026-09-11
Healthy Volunteers
Yes
Conditions
Interventions
Orforglipron
Oral, corresponding dose regimen according to study cohort (including Part B) .
Matching Placebo
Oral, matching to IBI3042, corresponding dose regimen according to study cohort (including Part A, Part B) .
IBI3042
Oral, corresponding dose regimen according to study cohort (including Part A, Part B) .
Locations (1)
Peking University First Hospital
Beijing, Beijing Municipality, China