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Evaluation of PTHrP, RANKL, and OPG Levels in Periodontal Health and Diseases
Sponsor: Abant Izzet Baysal University
Summary
This observational study aims to evaluate the levels of specific biological markers-Parathyroid Hormone-Related Protein (PTHrP), RANKL, and Osteoprotegerin (OPG)-in the gingival crevicular fluid of individuals with different gum health conditions. The study includes a total of 81 participants, divided equally into three groups: 27 with healthy gums, 27 with gingivitis, and 27 with periodontitis. During a routine dental visit, participants undergo a standard periodontal examination to measure clinical signs such as plaque levels, gum bleeding, and pocket depths. Additionally, small sterile paper strips are gently placed in the gum crevices for 30 seconds to collect fluid samples. These fluid samples are then analyzed in a laboratory to understand how these specific proteins relate to gum health and the severity of gum disease.
Official title: Evaluation of Gingival Crevicular Fluid Parathyroid Hormone-Related Protein (PTHrP), RANKL, and OPG Levels in Periodontal Health, Gingivitis, and Periodontitis.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
81
Start Date
2026-06-01
Completion Date
2026-08-31
Last Updated
2026-08-28
Healthy Volunteers
Yes
Interventions
Routine periodontal clinical examination and GCF collection
A comprehensive clinical periodontal examination is performed by a single calibrated examiner using a periodontal probe. The examination includes the measurement of Plaque Index (PI), Gingival Index (GI), PD, and CAL. For GCF collection, the specified interproximal sites are isolated with cotton rolls, gently air-dried, and cleared of supragingival plaque. GCF samples are then collected using sterile filter paper strips inserted into the sulcus until mild resistance is felt and left in place for 30 seconds.
Locations (1)
Bolu Abant İzzet Baysal University, Faculty of Dentistry, Department of Periodontology
Bolu, Gölköy, Turkey (Türkiye)