Clinical Research Directory

Inclusion Criteria: * Has radiographically measurable disease per protocol * If to receive oral study treatment, has the ability to swallow and retain oral medication and does not have gastrointestinal abnormalities that may alter absorption * Has well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy (ART) if diagnosed with HIV * Has adequate organ function per protocol Exclusion Criteria: * Has a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease if diagnosed with HIV * Has a history of posterior reversible encephalopathy syndrome (PRES) or seizure disorder * Has hepatic encephalopathy, hepatorenal syndrome, or Child-Pugh class B or more severe liver cirrhosis * Has a history of confirmed inflammatory bowel disease * Has a serious active nonhealing wound, ulcer, and/or bone fracture * Has a history of myocarditis or cardiomyopathy * Has a history of or current severe cardiovascular and cerebrovascular diseases * Is currently receiving any anticoagulants * Has a diagnosis of immunodeficiency * Has a known additional malignancy that is progressing or required active treatment within the past 3 years * Has known active central nervous system metastases and/or carcinomatous meningitis * Has active autoimmune disease that required systemic treatment in the past 2 years (hormonal supplementation \[eg, thyroxine, insulin, or physiologic corticosteroid\] is allowed) * Has a history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids or has current pneumonitis/ILD * Has a history of stem cell/solid organ transplant * Has not adequately recovered from major surgery or from central venous access device placement, or has ongoing surgical complications