Clinical Research Directory

Inclusion Criteria: * Adults aged 18 to 65 years. * Diagnosis of periodontitis according to the 2017 classification of periodontal and peri-implant diseases and conditions. * Presence of at least two clinically comparable periodontal sites within the same mouth that are suitable for a split-mouth design. * Periodontal probing depth of 5 mm or greater at the sites selected for randomization. * No systemic condition that would contraindicate nonsurgical periodontal therapy or adversely affect periodontal healing. * No current use of medications known to affect periodontal tissue healing. * No periodontal surgical treatment within the previous 6 months. * Ability to understand the study procedures, provide written informed consent, and attend the scheduled follow-up visits. Exclusion Criteria: * Current smoking or smoking cessation within the previous 6 months. * Diabetes mellitus, uncontrolled hypertension, serious cardiovascular disease, autoimmune disease, liver failure, kidney failure, or another systemic condition that may adversely affect periodontal healing or treatment. * Use of antibiotics, corticosteroids, bisphosphonates, antiresorptive agents, immunosuppressive agents, or other medications known to affect periodontal healing within the previous 6 months. * Pregnancy or lactation. * Acute periodontal abscess or acute endodontic infection at a selected study site. * Hematologic disease, bleeding disorder, anticoagulant therapy, or another condition that may interfere with venous blood collection. * Known hypersensitivity to any material used in the study. * Inadequate oral hygiene or inability to meet the oral hygiene requirements of the study protocol. * Current orthodontic treatment. * Inability or unwillingness to attend the scheduled follow-up visits.