Clinical Research Directory
Browse clinical research sites, groups, and studies.
Pancreatic Cancer Lifestyle Evolution And Resistance
Sponsor: IRCCS San Raffaele
Summary
Advanced PDAC patients undergo polychemotherapy, yet responses are highly variable. Transcriptome signatures are emerging as key predictors of treatment response. However, PDAC adapts across sites (primary vs. metastases) and evolves under treatment pressure (pre- vs. post-chemotherapy). Moreover, common environmental pollutants, like smoking and microplastics, contribute to carcinogenesis, yet their impact on PDAC evolution and treatment response remains unclear. To fill these gaps, the CLEAR project aims at investigating: 1. transcriptome patterns linked to treatment response; 2. effects of smoking and microplastic exposure on treatment outcomes; 3. PDAC evolution across organ sites and under chemotherapy. These studies will help uncover biomarkers and factors shaping disease progression, hence paving the ground for personalized therapies.
Official title: Decoding Environmental Drivers of Adaptive Evolution and Chemotherapy Resistance in Advanced Pancreatic Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2026-10-31
Completion Date
2029-10-31
Last Updated
2026-08-31
Healthy Volunteers
No
Conditions
Interventions
Endoscopic Ultrasound with FNA/FNB
After identification of the mass lesion, a tumor sample will be acquired with a standard FNA/FNB needle, as the standard procedure requires. The sample will be taken and stored in a Eppendorf Tube of 1.5ml pre-filled with 300μL 1-Thioglycerol/Homogenization solution \_Promega® then stored in a 80°C freezer and transferred every 2 weeks to the CRB for subsequent RNA-seq.