Clinical Research Directory

Inclusion Criteria: 1. Age 18-75 years, regardless of sex 2. Pathologically confirmed colon adenocarcinoma, clinical stage I-III without preoperative endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) 3. Planned curative surgical resection, no prior anti-tumor therapy (chemotherapy, radiotherapy, targeted therapy) before surgery 4. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 5. Tumor tissue positive for at least one driver mutation among KRAS, NRAS, BRAF, PIK3CA 6. Voluntary participation with signed written informed consent, good compliance with scheduled follow-up and blood collection. Exclusion Criteria: 1. Received neoadjuvant chemotherapy, radiotherapy or targeted therapy before surgery 2. History of other malignant tumors (excluding non-adenomatous colorectal neoplasms) 3. Pregnant or breastfeeding women 4. Severe concurrent systemic diseases that interfere with long-term follow-up or short-term survival (uncontrolled severe infection, organ failure, mental disorders, or other serious conditions) 5. Abnormal laboratory values or social/family factors judged by investigator to impede sample collection and follow-up 6. Simultaneous participation in other interventional clinical trials with mandatory assigned postoperative treatment regimen