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A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
Sponsor: Edgewise Therapeutics, Inc.
Summary
This is a Phase 2 placebo-controlled study to evaluate the safety and tolerability of different doses of EDG-15400 in adults with heart failure with preserved ejection fraction (HFpEF).
Official title: A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of EDG-15400 in Adults With Symptomatic Heart Failure With Preserved Ejection Fraction
Key Details
Gender
All
Age Range
30 Years - 84 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-08-25
Completion Date
2027-12
Last Updated
2026-10-13
Healthy Volunteers
No
Interventions
EDG-15400 25 mg
EDG-15400 administered orally, once daily
Placebo to match EDG-15400 25 mg or 50 mg
Placebo administered orally, once daily
EDG-15400 50 mg
EDG-15400 administered orally, once daily
Locations (28)
Local Institution - 1
Birmingham, Alabama, United States
Local Institution - 25
Little Rock, Arkansas, United States
Local Institution - 2
Beverly Hills, California, United States
Local Institution - 3
San Diego, California, United States
Local Institution - 4
Vista, California, United States
Local Institution - 24
Gainesville, Florida, United States
Local Institution - 5
Peoria, Illinois, United States
Local Institution - 26
Fort Wayne, Indiana, United States
Local Institution - 6
Indianapolis, Indiana, United States
Local Institution - 7
Houma, Louisiana, United States
Local Institution - 8
Baltimore, Maryland, United States
Local Institution - 9
Ypsilanti, Michigan, United States
Local Institution - 28
Minneapolis, Minnesota, United States
Local Institution - 10
Jackson, Mississippi, United States
Local Institution - 11
Kansas City, Missouri, United States
Local Institution - 12
St Louis, Missouri, United States
Local Institution - 13
New York, New York, United States
Local Institution - 14
Greensboro, North Carolina, United States
Local Institution - 15
Cincinnati, Ohio, United States
Local Institution - 27
Tulsa, Oklahoma, United States
Local Institution - 16
Mechanicsburg, Pennsylvania, United States
Local Institution - 17
Charleston, South Carolina, United States
Local Institution - 18
Dallas, Texas, United States
Local Institution - 19
Houston, Texas, United States
Local Institution - 20
Houston, Texas, United States
Local Institution - 21
Houston, Texas, United States
Local Institution - 22
Charlottesville, Virginia, United States
Local Institution - 23
Seattle, Washington, United States